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J Nat Prod. 2019 Feb 22;82(2):259-264. doi: 10.1021/acs.jnatprod.8b00635. Epub 2019 Jan 23.

Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis.

Author information

1
Natural Products Research Institute, College of Pharmacy , Seoul National University , 1 Gwanak-ro , Gwanak-gu, Seoul 08826 , Republic of Korea.
2
Department of Pharmacognosy , University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh City , 700000 , Vietnam.
3
College of Pharmacy , Dongduk Women's University , Seoul 02748 , Korea.

Abstract

The therapeutic potential of adiponectin regulation has received interest because of its association with diverse human disease conditions, such as diabetes, obesity, atherosclerosis, and cancer. Phenylethylchromone derivatives from Aquilaria malaccensis-derived agarwood promoted adiponectin secretion during adipogenesis in human bone marrow mesenchymal stem cells, and 5,6-dihydroxy-2-(2-phenylethyl)chromone (1) was identified as a new chromone derivative. A target identification study with the most potent adiponectin-secretion-promoting phenylethylchromones, 6-methoxy-2-(2-phenylethyl)chromone (3) and 7-methoxy-2-(2-phenylethyl)chromone (4), showed that they are PPARĪ³ partial agonists. Therefore, the diverse therapeutic effects of agarwood are associated with a PPARĪ³-mediated adiponectin-secretion-promoting mechanism.

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