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J Nat Prod. 2019 Feb 22;82(2):259-264. doi: 10.1021/acs.jnatprod.8b00635. Epub 2019 Jan 23.

Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis.

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Natural Products Research Institute, College of Pharmacy , Seoul National University , 1 Gwanak-ro , Gwanak-gu, Seoul 08826 , Republic of Korea.
Department of Pharmacognosy , University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh City , 700000 , Vietnam.
College of Pharmacy , Dongduk Women's University , Seoul 02748 , Korea.


The therapeutic potential of adiponectin regulation has received interest because of its association with diverse human disease conditions, such as diabetes, obesity, atherosclerosis, and cancer. Phenylethylchromone derivatives from Aquilaria malaccensis-derived agarwood promoted adiponectin secretion during adipogenesis in human bone marrow mesenchymal stem cells, and 5,6-dihydroxy-2-(2-phenylethyl)chromone (1) was identified as a new chromone derivative. A target identification study with the most potent adiponectin-secretion-promoting phenylethylchromones, 6-methoxy-2-(2-phenylethyl)chromone (3) and 7-methoxy-2-(2-phenylethyl)chromone (4), showed that they are PPARĪ³ partial agonists. Therefore, the diverse therapeutic effects of agarwood are associated with a PPARĪ³-mediated adiponectin-secretion-promoting mechanism.

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