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Med Sci (Paris). 2019 Jan;35(1):31-38. doi: 10.1051/medsci/2018310. Epub 2019 Jan 23.

[Quorum sensing and quorum quenching: how to disrupt bacterial communication to inhibit virulence?]

[Article in French]

Author information

1
Aix Marseille Univ, Institut de recherche pour le développement (IRD), Assistance Publique-Hôpitaux de Marseille (APHM), Microbes évolution phylogénie et infections (MEPHI), Institut hospitalo-universitaire (IHU)-Méditerranée Infection, 13005 Marseille, France.
2
Aix Marseille Univ, Institut de recherche pour le développement (IRD), Assistance Publique-Hôpitaux de Marseille (APHM), Microbes évolution phylogénie et infections (MEPHI), Institut hospitalo-universitaire (IHU)-Méditerranée Infection, 13005 Marseille, France - Gene&GreenTK, 19-21, boulevard Jean Moulin, 13005 Marseille, France.
3
Gene&GreenTK, 19-21, boulevard Jean Moulin, 13005 Marseille, France.

Abstract

Most bacteria use a communication system known as quorum sensing which relies on the secretion and perception of small molecules called autoinducers enabling bacteria to adapt their behavior according to the population size and synchronize the expression of genes involved in virulence, antimicrobial resistance and biofilm formation. Methods have emerged to inhibit bacterial communication and limit their noxious traits. Chemical inhibitors, sequestering antibodies and degrading enzymes have been developed and proved efficient to decrease bacterial virulence both in vitro and in vivo. This strategy, named quorum quenching, also showed synergistic effects with traditional antibacterial treatments by increasing bacterial susceptibility to antibiotics. Thereby quorum quenching constitutes an interesting therapeutic strategy to fight against bacterial infections and limit the consequences of antibiotic resistance.

PMID:
30672458
DOI:
10.1051/medsci/2018310

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