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Epigenomics. 2019 Feb;11(3):349-362. doi: 10.2217/epi-2018-0081. Epub 2019 Jan 23.

Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives.

Author information

1
Programa de Pós-graduação em Oncologia e Ciências Médicas, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
2
Programa de Pós-graduação em Química Medicinal e Modelagem Molecular, Universidade Federal do Pará, Belém, PA, Brazil.
3
Residência Multiprofissional em Saúde/Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil.
4
Disciplina de Genética, Universidade Federal de São Paulo, SP, Brazil.
5
Faculdade de Biotecnologia, Universidade Federal do Pará, Belém, PA, Brazil.
6
Departamento de Patologia, Universidade Federal de São Paulo, SP, Brazil.
7
Pró-Reitoria de Pesquisa e Pós-Graduação, Universidade do Sagrado Coração, Bauru, SP, Brazil.
8
Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém, PA, Brazil.

Abstract

Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative treatment and preventive strategies for cancer. For example, in gastric cancer, cholecalciferol, curcumin, resveratrol, quercetin, garcinol and sodium butyrate are natural regulators of acetylation and deacetylation enzyme activity that exert chemopreventive and anticancer effects. Here, we review the recent findings on histone acetylation in gastric cancer and discuss the effects of nutrients and bioactive compounds on histone acetylation and their potential role in the prevention and treatment of this type of cancer.

KEYWORDS:

bioactive compounds; cholecalciferol; curcumin; garcinol; histone acetyltransferase; histone deacetylase; nutrients; nutriepigenetics; quercetin; resveratrol; sodium butyrate

PMID:
30672330
DOI:
10.2217/epi-2018-0081

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