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Oxid Med Cell Longev. 2018 Dec 23;2018:6256052. doi: 10.1155/2018/6256052. eCollection 2018.

Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals.

Author information

1
Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigacion Sanitaria de Santiago (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.
2
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid, Spain.
3
Laboratory of Epigenomics in Endocrinology and Nutrition, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.
4
Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain.

Abstract

Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism. This study is aimed at evaluating the relationship between liver SIRT6 gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome. We observed that liver-specific SIRT6 expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome. We also observed that SIRT6 expression in the liver is positively associated with SIRT1 and GST-M2 expressions, two proteins involved in antioxidant protection pathways and inversely related to body weight and plasmatic oxidative status. Interestingly, the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers. These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease.

PMID:
30671172
PMCID:
PMC6317113
DOI:
10.1155/2018/6256052
[Indexed for MEDLINE]
Free PMC Article

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