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BMC Endocr Disord. 2019 Jan 22;19(1):11. doi: 10.1186/s12902-019-0343-x.

Plasma glucose in screening for diabetes and pre-diabetes: how much is too much? Analysis of fasting plasma glucose and oral glucose tolerance test in Sri Lankans.

Author information

1
Medical Research Institute, Colombo, 08, Sri Lanka.
2
Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
3
Cruddas Link Fellow, Harris Manchester University, University of Oxford, Oxford, UK.
4
Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, London, UK.
5
Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. dissanayakeha@gmail.com.
6
Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Abstract

BACKGROUND:

Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We aimed to establish FPG cut offs for Sri Lankans to screen for diabetes and pre-diabetes.

METHODS:

Data on FPG and diabetes/pre-diabetes status were obtained from Sri Lanka Diabetes and Cardiovascular Study (SLDCS), a community based island wide observational study conducted in 2005-6. Sensitivity specificity and area under the ROC curve were calculated for different FPG values.

RESULTS:

Study included 4014 community dwelling people after excluding people already on treatment for diabetes or pre-diabetes. Mean age was 45.3 (± 15) years and 60.4% were females. FPG cut off of 5.3 mmol/L showed better sensitivity and specificity than 5.6 mmol/L in detecting diabetes (87.8% and 84.4% Vs 80.8% and 92.1%) and pre-diabetes (54.7% and 87.0% Vs 43.8% and 94.2%).

CONCLUSIONS:

A lower FPG cut off of 5.3 mmol/L has a better sensitivity and acceptable specificity in screening for diabetes and pre-diabetes in Sri Lankan adults.

KEYWORDS:

Diabetes, pre-diabetes; Fasting plasma glucose; South Asia; Sri Lanka

PMID:
30670002
PMCID:
PMC6341544
DOI:
10.1186/s12902-019-0343-x
[Indexed for MEDLINE]
Free PMC Article

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