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Molecules. 2019 Jan 21;24(2). pii: E366. doi: 10.3390/molecules24020366.

Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases.

Author information

1
Thematic Task Force on Healthy Aging, CUECH Research Network, Santiago, Chile. mariane.lutz@uv.cl.
2
Interdisciplinary Center for Health Studies, CIESAL, Faculty of Medicine, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile. mariane.lutz@uv.cl.
3
Thematic Task Force on Healthy Aging, CUECH Research Network, Santiago, Chile. edfuentes@utalca.cl.
4
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Research Center for Aging, Universidad de Talca, 2 Norte 685, Talca 3460000, Chile. edfuentes@utalca.cl.
5
Thematic Task Force on Healthy Aging, CUECH Research Network, Santiago, Chile. favilac@utalca.cl.
6
Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile. favilac@utalca.cl.
7
Thematic Task Force on Healthy Aging, CUECH Research Network, Santiago, Chile. malarcon@utalca.cl.
8
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Research Center for Aging, Universidad de Talca, 2 Norte 685, Talca 3460000, Chile. malarcon@utalca.cl.
9
Thematic Task Force on Healthy Aging, CUECH Research Network, Santiago, Chile. ipalomo@utalca.cl.
10
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Research Center for Aging, Universidad de Talca, 2 Norte 685, Talca 3460000, Chile. ipalomo@utalca.cl.

Abstract

The population is now living longer during the period classified as "elderly" (60 years and older), exhibiting multimorbidity associated to the lengthening of the average life span. The dietary intake of phenolic compounds (PC) may affect the physiology, disease development and progression during the aging process, reducing risk factors of age related diseases. The aim of this review is to briefly describe some of the possible effects of a series of PC on the reduction of risk factors of the onset of cardiovascular diseases, considering their potential mechanisms of action. The main actions described for PC are associated with reduced platelet activity, anti-inflammatory effects, and the protection from oxidation to reduce LDL and the generation of advanced glycation end products. Preclinical and clinical evidence of the physiological effects of various PC is presented, as well as the health claims approved by regulatory agencies.

KEYWORDS:

age related diseases; aging; atherothrombosis; cardiovascular disease; health claims; oxidative stress; phenolic compounds; platelets

PMID:
30669612
PMCID:
PMC6359321
DOI:
10.3390/molecules24020366
[Indexed for MEDLINE]
Free PMC Article

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