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Int J Mol Sci. 2019 Jan 20;20(2). pii: E434. doi: 10.3390/ijms20020434.

Extracellular Vesicle-Mediated Cell⁻Cell Communication in the Nervous System: Focus on Neurological Diseases.

Author information

1
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy. celestebavisotto@gmail.com.
2
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, Italy. celestebavisotto@gmail.com.
3
Institute of Biophysics, National Research Council, 90143 Palermo, Italy. celestebavisotto@gmail.com.
4
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy. scalia.fede@gmail.com.
5
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, Italy. scalia.fede@gmail.com.
6
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy. antonella.marino@hotmail.it.
7
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, Italy. antonella.marino@hotmail.it.
8
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Biochemistry, University of Palermo, 90127 Palermo, Italy. daniela.carlisi@unipa.it.
9
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy. fabiobuk@gmail.com.
10
Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USA. econwaydemacario@som.umaryland.edu.
11
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, Italy. ajlmacario@som.umaryland.edu.
12
Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USA. ajlmacario@som.umaryland.edu.
13
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy. francapp@hotmail.com.
14
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, Italy. francapp@hotmail.com.
15
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy. claudiettacam@hotmail.com.

Abstract

Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell⁻cell communication in physiology and pathology.

KEYWORDS:

biomarkers; cell–cell interaction; central nervous system; exosomes; extracellular vesicles; nervous system; neurological diseases; theranostics tools

PMID:
30669512
PMCID:
PMC6359416
DOI:
10.3390/ijms20020434
[Indexed for MEDLINE]
Free PMC Article

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