Format

Send to

Choose Destination
Mar Drugs. 2019 Jan 18;17(1). pii: E61. doi: 10.3390/md17010061.

Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging.

Author information

1
School of Medicine, Jeju National University, Jeju 63243, Korea. yujae_1113@naver.com.
2
School of Medicine, Jeju National University, Jeju 63243, Korea. meijing0219@hotmail.com.
3
School of Medicine, Jeju National University, Jeju 63243, Korea. legna48@hanmail.net.
4
School of Medicine, Jeju National University, Jeju 63243, Korea. zhenaoxuan705@gmail.com.
5
School of Medicine, Jeju National University, Jeju 63243, Korea. sameeramadhu91@gmail.com.
6
School of Medicine, Jeju National University, Jeju 63243, Korea. pharmkhk@jejunu.ac.kr.
7
Choung Ryong Fisheries Co. LTD, 7825 Iljudong-ro, Namwon-epu, Seogwipo, Jeju 63612, Korea. ecoil@daum.net.
8
School of Medicine, Jeju National University, Jeju 63243, Korea. jinwonh@jejunu.ac.kr.

Abstract

Skin is exposed to various harmful environmental factors such as air pollution, which includes different types of particulate matter (PM). Atmospheric PM has harmful effects on humans through increasing the generation of reactive oxygen species (ROS), which have been reported to promote skin aging via the induction of matrix metalloproteinases (MMPs), which in turn can cause the degradation of collagen. In this study, we investigated the effect of fermented fish oil (FFO) derived from mackerel on fine PM (particles with a diameter < 2.5 µm: PM2.5)-induced skin aging in human keratinocytes. We found that FFO inhibited the PM2.5-induced generation of intracellular ROS and MMPs, including MMP-1, MMP-2, and MMP-9. In addition, FFO significantly abrogated the elevation of intracellular Ca2+ levels in PM2.5-treated cells and was also found to block the PM2.5-induced mitogen-activated protein kinase/activator protein 1 (MAPK/AP-1) pathway. In conclusion, FFO has an anti-aging effect on PM2.5-induced aging in human keratinocytes.

KEYWORDS:

fermented fish oil; matrix metalloproteinase; oxidative stress; particulate matter; skin aging

PMID:
30669248
PMCID:
PMC6356237
DOI:
10.3390/md17010061
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center