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Am J Primatol. 2019 Feb;81(2):e22952. doi: 10.1002/ajp.22952. Epub 2019 Jan 21.

Cross-sectional comparison of health-span phenotypes in young versus geriatric marmosets.

Author information

1
Department of Science and Mathematics, Texas A&M University San Antonio, San Antonio, Texas.
2
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
3
Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, Texas.
4
Department of Psychology, Trinity University, San Antonio, Texas.
5
Department of Medicine, University of Texas Health San Antonio, San Antonio, Texas.

Abstract

The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This cross-sectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment when compared to young animals. While geriatric animals did not show gross abnormalities in mobility and measures of locomotion, their types of movement were altered from young animals. Geriatric marmosets had alterations in cardiac function, with significantly increased mean arterial pressures; metabolism, with significantly lower VO2 ; and suppressed immune function. Further, this study sought to characterize and describe histopathology for both young and geriatric healthy marmosets. Overall this study provides a characterization of health parameters for young and geriatric marmosets which will greatly enhance future aging and interventional testing in marmosets.

KEYWORDS:

animal models; biomarkers of aging; healthspan; longevity; nonhuman primates

PMID:
30664265
DOI:
10.1002/ajp.22952

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