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J Vet Diagn Invest. 2019 Jan 19:1040638718823046. doi: 10.1177/1040638718823046. [Epub ahead of print]

Whole genome sequencing confirms source of pathogens associated with bacterial foodborne illness in pets fed raw pet food.

Jones JL1,2,3,4,5, Wang L1,2,3,4,5, Ceric O1,2,3,4,5, Nemser SM1,2,3,4,5, Rotstein DS1,2,3,4,5, Jurkovic DA1,2,3,4,5, Rosa Y1,2,3,4,5, Byrum B1,2,3,4,5, Cui J1,2,3,4,5, Zhang Y1,2,3,4,5, Brown CA1,2,3,4,5, Burnum AL1,2,3,4,5, Sanchez S1,2,3,4,5, Reimschuessel R1,2,3,4,5.

Author information

1
Office of Research (Jones, Ceric, Nemser, Reimschuessel), Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel and Rockville, MD.
2
Office of Surveillance and Compliance (Rotstein), Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel and Rockville, MD.
3
Veterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign College of Veterinary Medicine, Urbana, IL (Wang).
4
Ohio Animal Disease Diagnostic Laboratory, Ohio Department of Agriculture, Reynoldsburg, OH (Jurkovic, Rosa, Byrum, Cui, Zhang).
5
Athens Veterinary Diagnostic Laboratory, The University of Georgia College of Veterinary Medicine, Athens, GA (Brown, Burnum, Sanchez).

Abstract

Reports of raw meat pet food containing zoonotic foodborne bacteria, including Salmonella, Escherichia coli, and Listeria monocytogenes, are increasing. Contaminated raw pet food and biological waste from pets consuming those diets may pose a public health risk. The U.S. Food and Drug Administration Veterinary Laboratory Investigation and Response Network conducted 2 case investigations, involving 3 households with animal illnesses, which included medical record review, dietary and environmental exposure interviews, animal sample testing, and whole genome sequencing (WGS) of bacteria isolated from the pets and the raw pet food. For each case investigation, WGS with core genome multi-locus sequence typing analysis showed that the animal clinical isolates were closely related to one or more raw pet food bacterial isolates. WGS and genomic analysis of paired animal clinical and animal food isolates can confirm suspected outbreaks of animal foodborne illness.

KEYWORDS:

Bacteriology; cats; dogs; foodborne illness; raw pet food; whole genome sequencing

PMID:
30663530
DOI:
10.1177/1040638718823046

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