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Alzheimers Dement (N Y). 2018 Dec 18;4:756-764. doi: 10.1016/j.trci.2018.11.002. eCollection 2018.

The Age-Well observational study on expert meditators in the Medit-Ageing European project.

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Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France.
Swiss Center for Affective Sciences, Department of Medicine and Department of Psychology, University of Geneva, Geneva, Switzerland.
GIGA-CRC, In Vivo Imaging, Université de Liège, Liège, Belgium.
Belgian National Fund for Scientific Research (F.R.S.-FNRS), Bruxelles, Belgium.
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France.
Division of Psychiatry, University College London, London, United Kingdom.
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1077, GIP Cyceron, Caen, France.
CHU Caen-Normandie, Department of Clinical Research, Caen, France.
Department of Medicine, University of Geneva, Geneva, Switzerland.
EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, INSERM, Bordeaux Population Health Center, Bordeaux, France.
CHU Bordeaux, F-33000 Bordeaux, France.



The Age-Well observational, cross-sectional study investigates the affective and cognitive mechanisms of meditation expertise with behavioral, neuroimaging, sleep, and biological measures sensitive to aging and Alzheimer's disease (AD).


Thirty cognitively unimpaired individuals aged 65 years or older with at least 10,000 hours of practice in mindfulness meditation (MM) and loving-kindness and compassion meditation (LKCM) are selected. The outcomes are the neuroimaging brain correlates of MM and LKCM and the assessments of long-term meditation practices on behavioral, neural, and biological measures as compared to nonmeditator older controls from the Age-Well randomized controlled trial.


Recruitment and data collection began in late 2016 and will be completed by late 2019.


Results are expected to foster the understanding of the effects of meditation expertise on aging and of the mechanisms of action underlying the meditation intervention in the Age-Well randomized controlled trial. These finding will contribute to the design of meditation-based prevention randomized controlled trials for the aged population and to the exploration of the possible long-time developmental trajectory of meditation training.


Aging; Alzheimer's disease; Blood markers; Cognition; Compassion and loving-kindness meditation; Dementia; Emotion; Lifestyle; Meditation expertise; Mindfulness meditation; Neuroimaging; Prevention; Reserve; Sleep

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