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Alzheimers Dement (N Y). 2018 Dec 18;4:756-764. doi: 10.1016/j.trci.2018.11.002. eCollection 2018.

The Age-Well observational study on expert meditators in the Medit-Ageing European project.

Author information

1
Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France.
2
Swiss Center for Affective Sciences, Department of Medicine and Department of Psychology, University of Geneva, Geneva, Switzerland.
3
GIGA-CRC, In Vivo Imaging, Université de Liège, Liège, Belgium.
4
Belgian National Fund for Scientific Research (F.R.S.-FNRS), Bruxelles, Belgium.
5
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France.
6
Division of Psychiatry, University College London, London, United Kingdom.
7
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1077, GIP Cyceron, Caen, France.
8
CHU Caen-Normandie, Department of Clinical Research, Caen, France.
9
Department of Medicine, University of Geneva, Geneva, Switzerland.
10
EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, INSERM, Bordeaux Population Health Center, Bordeaux, France.
11
CHU Bordeaux, F-33000 Bordeaux, France.

Abstract

Introduction:

The Age-Well observational, cross-sectional study investigates the affective and cognitive mechanisms of meditation expertise with behavioral, neuroimaging, sleep, and biological measures sensitive to aging and Alzheimer's disease (AD).

Methods:

Thirty cognitively unimpaired individuals aged 65 years or older with at least 10,000 hours of practice in mindfulness meditation (MM) and loving-kindness and compassion meditation (LKCM) are selected. The outcomes are the neuroimaging brain correlates of MM and LKCM and the assessments of long-term meditation practices on behavioral, neural, and biological measures as compared to nonmeditator older controls from the Age-Well randomized controlled trial.

Results:

Recruitment and data collection began in late 2016 and will be completed by late 2019.

Discussion:

Results are expected to foster the understanding of the effects of meditation expertise on aging and of the mechanisms of action underlying the meditation intervention in the Age-Well randomized controlled trial. These finding will contribute to the design of meditation-based prevention randomized controlled trials for the aged population and to the exploration of the possible long-time developmental trajectory of meditation training.

KEYWORDS:

Aging; Alzheimer's disease; Blood markers; Cognition; Compassion and loving-kindness meditation; Dementia; Emotion; Lifestyle; Meditation expertise; Mindfulness meditation; Neuroimaging; Prevention; Reserve; Sleep

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