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J Microbiol Biotechnol. 2019 Mar 28;29(3):429-440. doi: 10.4014/jmb.1811.11023.

Comparison of the Gut Microbiota of Centenarians in Longevity Villages of South Korea with Those of Other Age Groups.

Kim BS1,2, Choi CW3,4, Shin H3,4, Jin SP3,4,5, Bae JS3,4,5, Han M3,4,5, Seo EY3,4, Chun J6, Chung JH3,4,5,7.

Author information

1
Department of Life Science, Hallym University, Chuncheon 24252, Republic of Korea.
2
Multidisciplinary Genome Institute, Hallym University, Chuncheon 24252, Republic of Korea.
3
Department of Dermatology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
4
Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
5
Department of Biomedical Science, Seoul National University Graduate School, Seoul 03080, Republic of Korea.
6
School of Biological Sciences and Inst. of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Republic of Korea.
7
Institute on Aging, Seoul National University, Seoul 03080, Republic of Korea.

Abstract

Several studies have attempted to identify factors associated with longevity and maintenance of health in centenarians. In this study, we analyzed and compared the gut microbiota of centenarians in longevity villages with the elderly and adults in the same region and urbanized towns. Fecal samples were collected from centenarians, elderly, and young adults in longevity villages, and the gut microbiota sequences of elderly and young adults in urbanized towns of Korea were obtained from public databases. The relative abundance of Firmicutes was found to be considerably higher in subjects from longevity villages than those from urbanized towns, whereas Bacteroidetes was lower. Age-related rearrangement of gut microbiota was observed in centenarians, such as reduced proportions of Faecalibacterium and Prevotella, and increased proportion of Escherichia, along with higher abundances of Akkermansia, Clostridium, Collinsella, and uncultured Christensenellaceae. Gut microbiota of centenarians in rehabilitation hospital were also different to those residing at home. These differences could be due to differences in diet patterns and living environments. In addition, phosphatidylinositol signaling system, glycosphingolipid biosynthesis, and various types of N-glycan biosynthesis were predicted to be higher in the gut microbiota of centenarians (corrected p < 0.05). These three metabolic pathways of gut microbiota can be associated with the immune status and healthy gut environment of centenarians. Although further studies are necessary to validate the function of microbiota between groups, this study provides valuable information on centenarians' gut microbiota.

KEYWORDS:

Centenarian; gut microbiota; longevity village; rehabilitation hospital

PMID:
30661321
DOI:
10.4014/jmb.1811.11023
[Indexed for MEDLINE]
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