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Chemosphere. 2019 Apr;221:493-499. doi: 10.1016/j.chemosphere.2018.12.193. Epub 2019 Jan 3.

Transgenerational impact of DEHP on body weight of Drosophila.

Author information

1
Department of Environmental Engineering, National Chung Hsing University, Taichung, 402, Taiwan.
2
Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan.
3
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan.
4
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan.
5
Department of Environmental Engineering, National Chung Hsing University, Taichung, 402, Taiwan. Electronic address: wpliao@nchu.edu.tw.
6
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan; Brain Diseases Research Center, China Medical University, Taichung, 40402, Taiwan. Electronic address: linwy@mail.cmu.edu.tw.

Abstract

Bis(2-ethylhexyl) phthalate (DEHP) is the most typical plasticizer and an environmental endocrine disruptor (EDC). DEHP is known to influence offspring fertility, growth, and obesity. However, the role of the DEHP as a transgenerational obesogen is still controversial. In this study, we used fruit flies (Drosophila melanogaster) to investigate where the exposure period, doses, and exposed parental sex are critical to change the body weight of the offspring. We found long-term but not short-term, and high-dose but low-dose exposure resulted in significant change. Moreover, we found DEHP treatment on the father or mother Drosophila resulted in increased or decreased body weight of the offspring respectively. Our results demonstrated the heterogeneity of transgenerational impact of DEHP and highlighted the involvement of parental endocrine system in its role as an obesogen.

KEYWORDS:

DEHP; Drosophila melanogaster; Obesity; Transgeneration

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