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Sleep Med. 2019 Feb;54:262-265. doi: 10.1016/j.sleep.2018.10.033. Epub 2018 Nov 24.

The lullaby of the sun: the role of vitamin D in sleep disturbance.

Author information

1
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy. Electronic address: giovanna.muscogiuri@gmail.com.
2
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.
3
IRCCS SDN, Napoli Via Gianturco 113, 80143, Naples, Italy.
4
IRCCS, Istituto Auxologico Italiano, Div. General Medicine, Ospedale San Giuseppe, Piancavallo, Verbania, Italy.
5
Università del Piemonte Orientale, Endocrinologysss, Dept. Translational Medicine, Novara.
6
IRCCS, Istituto Auxologico Italiano, Div. General Medicine, Ospedale San Giuseppe, Piancavallo, Verbania, Italy; Università del Piemonte Orientale, Endocrinologysss, Dept. Translational Medicine, Novara.

Abstract

Vitamin D is a pro-hormone belonging to the category of the fat-soluble group of vitamins; it is obtained more from solar exposure and in smaller quantities through feeding. Although vitamin D has traditionally been shown to be involved in calcium homeostasis and bone health, recent studies have found a positive association between vitamin D and sleep. In particular, clinical studies in humans indicate that low levels of vitamin D are correlated with poor quality and short sleep duration. The mechanism by which this association is explained is still unclear. However, vitamin D receptors have been found in the brain regions involved in sleep regulation, and vitamin D appears to be involved in regulating the sleep-wake cycle. The current review summarizes the available evidence regarding the association between vitamin D and sleep, focusing on both clinical and preclinical studies.

KEYWORDS:

Sleep; Sleep disturbance; Sun; Vitamin; Vitamin D

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