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Int J Biol Macromol. 2019 Apr 15;127:440-449. doi: 10.1016/j.ijbiomac.2019.01.069. Epub 2019 Jan 17.

Fabrication of Konjac glucomannan-based composite hydrogel crosslinked by calcium hydroxide for promising lacrimal plugging purpose.

Author information

1
School of Chemical Engineering, Northwest University, Xi'an, PR China; Medical college, Xi'an International University, Xi'an, PR China.
2
Shaanxi Institute of Ophthalmology, Key Laboratory of Ophthalmology and Center for Clinical Medicine of Ophthalmology, Xi'an, PR China.
3
School of Chemical Engineering, Northwest University, Xi'an, PR China.
4
School of Chemical Engineering, Northwest University, Xi'an, PR China. Electronic address: Huiyunwen@nwu.edu.com.
5
School of Chemical Engineering, Northwest University, Xi'an, PR China. Electronic address: xuewm@nwu.edu.cn.

Abstract

Swelling, mechanical strength, flexibility, and toughness are important parameters in hydrogel preparation for application in the human body. Herein, composite hydrogels were prepared using a mix of Konjac glucomannan (KGM), sodium alginate (SA), and polyvinyl alcohol (PVA) cross-linked by calcium hydroxide. The PVA/KGM/SA composite hydrogel showed a suitable swelling ratio and rate, as well as elasticity and flexibility. In addition, the elongation at break was 660.3%, with a breaking strength of 87.25 kPa and a compression modulus of 1.660 MPa. Rheological studies showed that the composite hydrogel was composed of a multiply cross-linked network involving chemical and physical interactions, thereby affecting the elasticity and flexibility of the gel. Interestingly, the composite gel network was reformed when the temperature decreased. In rabbit models of dry eye, the hydrogel effectively maintained the normal tear meniscus height and increased the low tear meniscus area. The results therefore showed that the PVA/KGM/SA gels not only provide a simple, effective, and safe method for the preparation of hydrogels, but also have potential applications in the treatment of dry eye syndrome.

KEYWORDS:

Konjac glucomannan; Mechanical strength; Swelling behaviors

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