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Arch Toxicol. 2019 Mar;93(3):743-751. doi: 10.1007/s00204-019-02391-z. Epub 2019 Jan 18.

Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring's sex ratio.

Author information

1
Faculty of Pharmacy, Department of Toxicology, Ankara University, Tandoğan, 06100, Ankara, Turkey. duydu@pharmacy.ankara.edu.tr.
2
Faculty of Pharmacy, Department of Toxicology, Hacettepe University, Sıhhiye, 06100, Ankara, Turkey.
3
Faculty of Pharmacy, Department of Toxicology, Ankara University, Tandoğan, 06100, Ankara, Turkey.
4
Faculty of Medicine, Department of Urology, Ankara University, Ankara, Turkey.
5
Faculty of Medicine, Department of Gynecology and Obstetrics, Ankara University, Ankara, Turkey.
6
Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardey Str. 67, 44139, Dortmund, Germany.
7
Faculty of Statistics, TU Dortmund University, 44221, Dortmund, Germany.
8
Institute of Nutritional Science, Department of Food Chemistry, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

Abstract

Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest ("extreme") exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 ± 18.32 mg B/day, 1643.23 ± 965.44 ng B/g semen and 553.83 ± 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.

KEYWORDS:

Boron exposure; Paternal exposure; Sex ratio at birth; Y:X chromosome ratio

PMID:
30659322
DOI:
10.1007/s00204-019-02391-z

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