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Vet Res. 2019 Jan 18;50(1):5. doi: 10.1186/s13567-019-0625-3.

Antiviral activity of itraconazole against type I feline coronavirus infection.

Author information

1
School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan.
2
School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan. hohdatsu@vmas.kitasato-u.ac.jp.

Abstract

Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.

PMID:
30658691
PMCID:
PMC6339390
DOI:
10.1186/s13567-019-0625-3
[Indexed for MEDLINE]
Free PMC Article

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