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Environ Int. 2019 Mar;124:236-248. doi: 10.1016/j.envint.2019.01.001. Epub 2019 Jan 16.

Long-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort.

Author information

1
Département Cancer Environnement, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France; Université de Lyon, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100 Villeurbanne, France. Electronic address: Aurelie.DANJOU@lyon.unicancer.fr.
2
Département Cancer Environnement, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France; Université de Lyon, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100 Villeurbanne, France. Electronic address: Thomas.COUDON@lyon.unicancer.fr.
3
Département Cancer Environnement, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 28 rue Laënnec, 69373 Lyon Cedex 08, France. Electronic address: Delphine.PRAUD@lyon.unicancer.fr.
4
Université de Bordeaux, Institut de Santé Publique, d'Épidémiologie et de Développement, Centre Inserm U1219 Epidemiology and Biostatistics, 146 rue Léo Saignat, 33076 Bordeaux, France. Electronic address: Emilie.Leveque@u-bordeaux.fr.
5
Département Cancer Environnement, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France. Electronic address: Elodie.FAURE@lyon.unicancer.fr.
6
Laboratoire de Mécanique des Fluides et d'Acoustique, UMR CNRS 5509, Université de Lyon, Ecole Centrale de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, 36 avenue Guy de Collongue, 69134 Ecully Cedex, France. Electronic address: pietro.salizzoni@ec-lyon.fr.
7
Université de Lyon, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100 Villeurbanne, France; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 28 rue Laënnec, 69373 Lyon Cedex 08, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 28 rue Laënnec, 69373 Lyon Cedex 08, France. Electronic address: Muriel.LEROMANCER-CHERIFI@lyon.unicancer.fr.
8
Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, 114 rue Edouard-Vaillant, 94805 Villejuif Cedex, France. Electronic address: gianluca.severi@gustaveroussy.fr.
9
Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, 114 rue Edouard-Vaillant, 94805 Villejuif Cedex, France. Electronic address: francesca.mancini@gustaveroussy.fr.
10
Université de Bordeaux, Institut de Santé Publique, d'Épidémiologie et de Développement, Centre Inserm U1219 Epidemiology and Biostatistics, 146 rue Léo Saignat, 33076 Bordeaux, France. Electronic address: Karen.Leffondre@u-bordeaux.fr.
11
Département Cancer Environnement, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France; Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, 114 rue Edouard-Vaillant, 94805 Villejuif Cedex, France. Electronic address: DossusL@iarc.fr.
12
Département Cancer Environnement, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon Cedex 08, France; Université de Lyon, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100 Villeurbanne, France; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 28 rue Laënnec, 69373 Lyon Cedex 08, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 28 rue Laënnec, 69373 Lyon Cedex 08, France. Electronic address: Beatrice.FERVERS@lyon.unicancer.fr.

Abstract

BACKGROUND:

Dioxins, Group 1 carcinogens, are emitted by industrial chlorinated combustion processes and suspected to increase breast cancer risk through receptor-mediated pathways.

OBJECTIVES:

We estimated breast cancer risk associated with airborne dioxin exposure, using geographic information system (GIS) methods and historical exposure data.

METHODS:

We designed a case-control study (429 breast cancer cases diagnosed between 1990 and 2008, matched to 716 controls) nested within the E3N (Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale) cohort. Airborne dioxin exposure was assessed using a GIS-based metric including participants' residential history, technical characteristics of 222 dioxin sources, residential proximity to dioxin sources, exposure duration and wind direction. Odds ratios (OR) and 95% confidence intervals (CI) associated with quintiles of cumulative exposure were estimated using multivariate logistic regression models.

RESULTS:

We observed no increased risk of breast cancer for higher dioxin exposure levels overall and according to hormone-receptor status. We however observed a statistically significant OR for Q2 versus Q1 overall (1.612, 95% CI: 1.042-2.493) and for estrogen-receptor (ER) positive breast cancer (1.843, 95% CI: 1.033-3.292).

CONCLUSIONS:

Overall, as well as according to hormone-receptor status, no increased risk was observed for higher airborne dioxin exposure. The increased risk for low exposure levels might be compatible with non-monotonic dose-response relationship. Confirmation of our findings is required. Our GIS-based metric may provide an alternative in absence of ambient dioxin monitoring and may allow assessing exposure to other pollutants.

KEYWORDS:

Breast cancer; Dioxins; Endocrine disruptors; Geographic information system; Tumor receptor

PMID:
30658268
DOI:
10.1016/j.envint.2019.01.001
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