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Papillomavirus Res. 2019 Jan 15;7:52-61. doi: 10.1016/j.pvr.2019.01.002. [Epub ahead of print]

Pre-vaccination prevalence of anogenital and oral human papillomavirus in young HIV-infected men who have sex with men.

Author information

1
Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: jessica.kahn@cchmc.org.
2
Department of Pediatrics, University of Southern California, Los Angeles, CA, USA. Electronic address: mbelzer@chla.usc.edu.
3
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: XChi@uams.edu.
4
Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: JYLee@uams.edu.
5
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: Aditya.Gaur@STJUDE.ORG.
6
Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: KMayer@fenwayhealth.org.
7
John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, USA. Electronic address: Jaime.Martinez@gilead.com.
8
Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: DFutterman@AdolescentAIDS.org.
9
Boston University School of Medicine, Boston, MA, USA. Electronic address: Elizabeth.Stier@bmc.org.
10
Baylor College of Medicine, Houston, TX, USA. Electronic address: mepaul@texaschildrenshospital.org.
11
Baylor College of Medicine, Houston, TX, USA. Electronic address: echiao@bcm.edu.
12
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: daniel.reirden@childrenscolorado.org.
13
Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: goldstone.stephen@gmail.com.
14
Cancer Control and Population Sciences Program, University of Puerto Rico, San Juan, PR, USA. Electronic address: ana.ortiz7@upr.edu.
15
Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA. Electronic address: ecachay@ucsd.edu.
16
Department of Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA. Electronic address: lbarroso@wakehealth.edu.
17
Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Electronic address: Maria.DaCosta@ucsf.edu.
18
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: cwilson@uab.edu.
19
Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Electronic address: Joel.Palefsky@ucsf.edu.

Abstract

The aims of this study were to: 1) determine prevalence of anogenital and oral HPV, 2) determine concordance between HPV at anal, perianal, scrotal/penile, and oral sites; and 3) describe factors associated with anogenital HPV types targeted by the 9-valent vaccine. Data were collected from 2012 to 2015 among men who have sex with men 18-26 years of age enrolled in a vaccine trial (N = 145). Penile/scrotal, perianal, anal, and oral samples were tested for 61 HPV types. Logistic regression was used to identify factors associated with types in the 9-valent vaccine. Participants' mean age was 23.0 years, 55.2% were African-American, and 26.2% were Hispanic; 93% had anal, 40% penile, and 6% oral HPV. Among those with anogenital infection, 18% had HPV16. Concordance was low between anogenital and oral sites. Factors independently associated with a 9-valent vaccine-type HPV were: race (African-American vs. White, OR=2.67, 95% CI=1.11-6.42), current smoking (yes vs. no, OR=2.37, 95% CI=1.03-5.48), and number of recent receptive anal sex partners (2+ vs. 0, OR=3.47, 95% CI=1.16-10.4). Most MSM were not infected with HPV16 or HPV18, suggesting that they may still benefit from HPV vaccination, but anogenital HPV was very common, highlighting the importance of vaccinating men before sexual initiation. CLINICAL TRIAL NUMBER: NCT01209325.

KEYWORDS:

Adolescents; Clinical trials; HIV; Human papillomavirus; Men who have sex with men; Vaccine

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