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Cell Chem Biol. 2019 Jan 17;26(1):1-3. doi: 10.1016/j.chembiol.2018.12.010.

Role of Bile in Infectious Disease: the Gall of 7α-Dehydroxylating Gut Bacteria.

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Department of Pathology & Immunology, Baylor College of Medicine, Houston TX, 77030, USA; Texas Children's Microbiome Center, Texas Children's Hospital, Houston TX, 77030, USA. Electronic address:
Department of Biology, Texas A&M University, College Station TX, 77843, USA.


Local antibiotics and quorum sensors produced by gut bacteria regulate microbiota community structure and guard against pathogens. In this issue of Cell Chemical Biology, Kang et al. (2019) guide us through a reciprocal host-antimicrobial interplay that redefines our understanding of Clostridioides (Clostridium) difficile pathogenesis.

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