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J Clin Endocrinol Metab. 2019 Jan 16. doi: 10.1210/jc.2018-02094. [Epub ahead of print]

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.

Author information

1
MediCity, University of Turku, Turku, Finland.
2
Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
3
Department of Biostatistics, University of Turku, Turku, Finland.
4
Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
5
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
6
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
7
Public Health Promotion Unit, Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
8
Faculty of Social Sciences/Health Sciences, University of Tampere, Tampere, Finland.
9
Tampere Center for Child Health Research, Tampere University and University Hospital and Science Center, Tampere University Hospital, Tampere, Finland.
10
Department of Virology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
11
Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
12
Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, and Clinical Microbiology, Turku University Hospital, Turku, Finland.
13
Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
14
Folkhälsan Research Center, Helsinki, Finland.
15
Department of Pediatrics, PEDEGO Research Unit, Medical Research Center Oulu, University of Oulu, Oulu, Finland.
16
Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

Abstract

Context:

Vitamin D has several effects on the immune system that might be of relevance for the pathogenesis of type 1 diabetes (T1D).

Objective:

To evaluate whether umbilical cord serum concentrations of 25-hydroxy-vitamin D (25[OH]D) differ in children developing either islet autoimmunity (IA) or overt T1D during childhood and adolescence.

Design:

Umbilical cord serum samples from 764 children born 1994-2004 with HLA-DQB1 conferred risk for type 1 diabetes (T1D) participating in the Type 1 Diabetes Prediction and Prevention Study (DIPP) were analyzed for 25(OH)D using an enzyme immunoassay.

Setting:

DIPP clinics in Turku, Oulu, and Tampere University Hospitals, Finland. The participants comprised 250 case children who developed T1D diabetes at a median age of 6.7 years (interquartile range [IQR] 4.0-10.1 years) and 132 additional case children who developed IA, i.e. positivity for multiple islet autoantibodies. Cases were matched for date of birth, sex and area of birth with 382 control children who remained autoantibody negative. The median duration of follow-up was 9.8 years (IQR 5.7-13.1 years).

Main Outcome Measure:

The median 25(OH)D concentrations.

Results:

The median 25(OH)D concentration in cord serum was low (31.1 nmol/L [IQR 24.0-41.8]; 88% < 50 nmol/L), but not statistically different between children who developed T1D or IA and their control groups (P=0.70). The levels were associated mainly with geographical location, year and month of birth, age of the mother and maternal intake of vitamin D during pregnancy.

Conclusions:

The 25(OH)D concentrations at birth are not associated with the development of T1D during childhood.

PMID:
30657906
DOI:
10.1210/jc.2018-02094

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