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PLoS One. 2019 Jan 18;14(1):e0210320. doi: 10.1371/journal.pone.0210320. eCollection 2019.

Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study.

Author information

1
Institute of Biochemistry and Clinical Biochemistry, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma-Università Cattolica del Sacro Cuore, Roma, Italy.
2
Internal Medicine Department, Division of Endocrinology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma-Università Cattolica del Sacro Cuore, Roma, Italy.
3
Internal Medicine Department, Division of Internal Medicine and Cardiovascular Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma-Università Cattolica del Sacro, Roma, Italy.
4
Institute of General Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma-Università Cattolica del Sacro Cuore, Roma, Italy.
5
Hospital Medical Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma-Università Cattolica del Sacro Cuore, Roma, Italy.

Abstract

Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.

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