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J Cell Physiol. 2019 Jan 17. doi: 10.1002/jcp.28164. [Epub ahead of print]

Expression profile of circular RNA in rat intimal hyperplasia and target gene prediction.

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Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institution of Cardiovascular Research, Southwest Medical University, Luzhou, China.
Department of Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Anatomy, Southwest Medical University, Luzhou, China.
Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Clinical Medicine, School of Clinical Medicine, Southwest Medical University, Luzhou, China.


Intimal hyperplasia is an important cause of stenosis or occlusion after vascular injury. Circular RNAs (circRNAs) are known to be related to various cardiovascular diseases. However, the expression profile of circRNAs in the neointima has not been reported in detail. In this study, we established a rat common carotid artery (CCA) injury model. A microarray detection showed significant differences in circRNA expression between the normal and injured CCA. Real-time quantitative polymerase chain reaction verified the differences. We used bioinformatics to predict the microRNAs that possibly interact with the differentially expressed (DE) circRNAs and linked the potential functions of circRNAs to the target genes of the microRNAs. We believe that the DE circRNA in neointima may affect the differentiation, proliferation, and migration of vascular cells through a variety of target genes. The intervention or utilization of certain circRNAs should be a new method for preventing and treating intimal hyperplasia.


circular RNA (circRNAs); intimal hyperplasia; phenotypic transformation; vascular remodeling


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