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J Phys D Appl Phys. 2018 Aug;51(34). pii: 343001. doi: 10.1088/1361-6463/aacb98. Epub 2018 Jul 20.

The 2018 biomembrane curvature and remodeling roadmap.

Author information

1
Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005 Paris, France.
2
Sorbonne Université, 75005 Paris, France.
3
Chemistry Department, University of Pennsylvania, Philadelphia, PA 19104-6323, United States of America.
4
Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213, United States of America.
5
Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14424 Potsdam, Germany.
6
Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country, Leioa 48940, Spain.
7
IKERBASQUE, Basque Foundation for Science, Bilbao 48013, Spain.
8
Federal Research and Clinical Centre of Physical-Chemical Medicine, Moscow 119435, Russia.
9
A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow 119071, Russia.
10
Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
11
Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
12
Department of Theoretical Physics, Georg-August University, Göttingen, Germany.
13
Cellular and Chemical Biology Unit, Institut Curie, PSL Research University, U1143 INSERM, UMR3666 CNRS, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
14
Sackler Faculty of Medicine, Department of Physiology and Pharmacology, Tel Aviv University.
15
Indian Institute of Science Education and Research, Pune, India.
16
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, United States of America.
17
University of Texas at Austin, Institute for Cellular and Molecular Biology, Austin, TX, United States of America.
18
Bionanotechnology and Nanomedicine Laboratory, Department of Chemistry, Nano-Science Center, University of Copenhagen, Denmark.
19
Department of Chemistry, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, United States of America.

Abstract

The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane morphology are involved in a plethora of phenomena involving the plasma membrane of eukaryotic cells, including endo- and exocytosis, phagocytosis and filopodia formation. On the other hand, a multitude of intracellular processes at the level of organelles rely on generation, modulation, and maintenance of membrane curvature to maintain the organelle shape and functionality. The contribution of biophysicists and biologists is essential for shedding light on the mechanistic understanding and quantification of these processes. Given the vast complexity of phenomena and mechanisms involved in the coupling between membrane shape and function, it is not always clear in what direction to advance to eventually arrive at an exhaustive understanding of this important research area. The 2018 Biomembrane Curvature and Remodeling Roadmap of Journal of Physics D: Applied Physics addresses this need for clarity and is intended to provide guidance both for students who have just entered the field as well as established scientists who would like to improve their orientation within this fascinating area.

KEYWORDS:

biomembrane; curavture; remodeling

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