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Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2). pii: a003434. doi: 10.1101/mcs.a003434. Print 2019 Apr.

Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report.

Author information

1
Clinical Center Vitamed, Moscow, 121309, Russia.
2
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia.
3
FSBEI FPE Russian Medical Academy of Continuing Professional Education MOH, Moscow, 125993, Russia.
4
Department of Pathology, Morozov Children's City Hospital, Moscow, 119049, Russia.
5
Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, 119991, Russia.
6
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russia.
7
Oncological Dispensary of the Republic of Karelia, Petrozavodsk, 185002, Russia.
8
The Institute of General Pathology and Pathophysiology, Moscow, 125315, Russia.
9
Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease.

KEYWORDS:

ovarian neoplasm

PMID:
30655270
DOI:
10.1101/mcs.a003434
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