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West J Nurs Res. 2019 Jul;41(7):990-1008. doi: 10.1177/0193945918823347. Epub 2019 Jan 17.

The Effect of an HIV Self-Management Intervention on Neurocognitive Behavioral Processing.

Author information

1
1 Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
2
2 University Hospitals Harrington Heart & Vascular Institute, Cleveland, OH, USA.
3
3 Kent State University, OH, USA.

Abstract

People living with HIV (PLHIV) are increasingly diagnosed with comorbidities which require increasing self-management. We examined the effect of a self-management intervention on neurocognitive behavioral processing. Twenty-nine PLHIV completed a two-group, 3-month randomized clinical trial testing a self-management intervention to improve physical activity and dietary intake. At baseline and 3 months later, everyone completed validated assessments of physical, diet, and neurocognitive processing (functional magnetic resonance imaging [fMRI]-derived network analyses). We used linear mixed effects modeling with a random intercept to examine the effect of the intervention. The intervention improved healthy eating (p = .08) but did not improve other self-management behaviors. There was a significant effect of the intervention on several aspects of neurocognitive processing including in the task positive network (TPN) differentiation (p = .047) and an increase in the default mode network (DMN) differentiation (p = .10). Self-management interventions may influence neurocognitive processing in PLHIV, but those changes were not associated with positive changes in self-management behavior.

KEYWORDS:

HIV; behavioral interventions; exercise; fMRI

PMID:
30654713
PMCID:
PMC6570548
[Available on 2020-07-01]
DOI:
10.1177/0193945918823347

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