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Hum Reprod. 1988 Aug;3(6):803-6.

Mifepristone (RU486) and therapeutic late pregnancy termination: a double-blind study of two different doses.

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Department of Gynaecology and Obstetrics, Hôpital Antoine Béclère, Clamart, France.


An antiprogesterone, mifepristone (RU486), was administered to 35 patients undergoing a therapeutic interruption of pregnancy during the second and third trimester for maternal or fetal indications. A randomized double-blind study test was performed using 150 and 450 mg of mifepristone as pretreatment prior to prostaglandins. No toxicity or maternal morbidity were recorded. In three patients the onset of labour occurred spontaneously before prostaglandin administration. Mifepristone produced a modification in the consistency of the cervix with a statistical improvement in cervical calibration in the two groups, but the cervical effect was independent of the dose.


Doses of 150 and 450 mg RU-486 (mifepristone) were compared in a randomized double-blind trial for 2nd or 3rd trimester termination of pregnancy. The 35 women averaged 22.5 weeks gestation (range 15-34); indications were maternal (HIV infection or psychiatric), and fetal, including major genetic, chromosomal or fetal abnormalities not compatible with life. RU-486 was given orally in 9 50 mg tablets or placebos 48 hours before hospitalization. The evening upon entering the hospital they received 1.5 mg PGE2 in a vaginal suppository. Labor had ensued in 3 women before receiving PG. 150 mg of RU-486 improved cervical softening score from 0.73 to 3.3, and a cervical dilatation, judging by Hegar dilators, from 7.1 to 12.75. The 450 mg dose improved cervical score from 0.72 to 3.12, and cervical dilatation from 6.3 to 11.9 (mean n.s.). The mean interval to abortion in women 20 weeks gestation or more was 19.54 hours in the 150 mg group and 8.6 hours in the 450 mg group (n.s.). Those less than 20 weeks gestation were terminated by dilation and evacuation under general anesthesia. There were no clinical or hematological side effects. 5 patients have subsequently had normal full-term deliveries. This drug may be useful to help dilate the cervix, shorten the abortion time, and reduce the dose of prostaglandin needed. No side effects have been reported with these doses of RU-486 combined with prostaglandin for midtrimester abortion.

[Indexed for MEDLINE]

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