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J Burn Care Rehabil. 1988 Nov-Dec;9(6):640-2.

Evaluation of the effect of topical steroids on human scar contracture using a nude mouse model.

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Shriners Burns Institute, Cincinnati Unit.


Adult nude mice had 1.5 to 1.0 meshed split-thickness human skin applied to an excised area of their back. The animals were then randomized into two groups, one of which had a steroid cream applied to their graft on alternate days. The other group had no ointment applied and served as a control. The wounds were measured on a weekly basis and the rate of wound contracture was found to be identical. Topical steroids would thus appear to offer no benefit in the prevention of scar contracture.

[Indexed for MEDLINE]

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