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Medicine (Baltimore). 2019 Jan;98(3):e14158. doi: 10.1097/MD.0000000000014158.

A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient.

Author information

1
Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University.
2
Department of Pediatrics, the Second People's Hospital of Changzhou, Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China.

Abstract

RATIONALE:

Fungal infection of gastrointestinal (GI) tract is usually seen in immunocompromised patients, but can rarely occur in immunocompetent people in whom no permissive factor is present.

PATIENT CONCERNS:

We describe a 68-year-old male immunocompetent patient presenting with simultaneous fungal esophagitis and giant gastric ulcer.

DIAGNOSES:

Repeated endoscopic biopsies were taken from the giant gastric ulcer edge and base and histology demonstrated granulation tissue and pseudohyphal fungal forms.

INTERVENTIONS:

The patient was treated with fluconazole and omeprazole for 8 weeks.

OUTCOMES:

After antifungal treatment with fluconazole, the patient's clinical symptoms gradually disappeared with the healing of gastric ulcer, which never recurred in this patient until 3 months after follow-up.

LESSONS:

Nonhealing gastroesophageal ulcers highlights the importance of repeated endoscopies and biopsies.

PMID:
30653156
PMCID:
PMC6370008
DOI:
10.1097/MD.0000000000014158
[Indexed for MEDLINE]
Free PMC Article

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