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Clin Exp Dermatol. 2019 Aug;44(6):637-642. doi: 10.1111/ced.13864. Epub 2019 Jan 16.

Association of interleukin-6 gene promoter polymorphism with acne vulgaris and its severity.

Author information

1
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
2
Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Abstract

BACKGROUND:

Acne vulgaris (AV) is an inflammatory disorder with a possible genetic background. Different cytokines and mediators are involved in its pathogenesis.

AIM:

Our aim was to investigate the interleukin (IL)-6 572 polymorphism in patients with AV and its relation to patient sex and acne severity.

METHODS:

In total, 30 patients with acne and 20 healthy controls (HCs) were enrolled. The Global Acne Grading System was used to assess acne severity. The IL-6 572 gene promoter polymorphism was assessed using the PCR-restriction fragment length polymorphism method.

RESULTS:

There was a significantly higher association of IL-6 572 variants genotypes in patients with acne (93%) compared with the HC group (45%) (P < 0.001), with a higher incidence of the IL-6 572 CC polymorphism in patients with acne. A significant difference (P < 0.001) between C and G alleles in patients vs. HCs was detected. There were no significant associations between the IL-6 572 variant genotypes and either patient sex or AV severity.

CONCLUSION:

IL-6 gene promoter polymorphism might have a role in AV susceptibility but it is not related to AV severity.

PMID:
30652337
DOI:
10.1111/ced.13864

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