Send to

Choose Destination
J Oral Maxillofac Pathol. 2018 Sep-Dec;22(3):382-391. doi: 10.4103/jomfp.JOMFP_223_18.

A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach.

Author information

Department of Oral Medicine and Maxillofacial Radiology, K.M. Shah Dental College and Hospital, Sumandeep Vidyapeeth University, Vadodara, Gujarat, India.
Department of Plastic and Reconstructive Surgery, Chinese PLA General Hospital, Beijing, China.
Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.


Oral submucous fibrosis (OSMF) is a chronic, progressive, debilitating, scarring and crippling disorder of the oral cavity. It is a potentially malignant oral disease which predominantly affects people of South and Southeast Asia, especially Indian subcontinent, where chewing of areca nut and its commercial preparation is rampant. However, due to increase in immigration of people from the Indian subcontinent, the health professionals in many developed countries do come across this disease very often. Since decades, many treatment modalities are suggested and studied using medicines, surgery and physiotherapy, with varying degrees of benefit, but none have been able to cure this disease completely, and hence, it has become a challenging condition. The present article emphasizes on various therapeutic interventions used till date to curb the menace of this disease and the principal author with his vast academic research and clinical experience in treating this disease has proposed the stage-wise treatment regimen for OSMF. The current article is an attempt to compile the available treatment, its current status and future perspectives, so as to assist early intervention of the disease with evidence-based approach. This article will ignite the research minds of dental clinician, oral medicine specialist, otolaryngologist and general physician in treating OSMF.


Areca nut; evidence-based treatment; oral submucous fibrosis; protocol; therapeutic interventions; tobacco

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center