Format

Send to

Choose Destination
Chem Commun (Camb). 2019 Jan 31;55(11):1568-1571. doi: 10.1039/c8cc10004g.

Coordination microparticle vaccines engineered from tumor cell templates.

Author information

1
Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China. bmemgl@126.com.

Abstract

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

PMID:
30648704
DOI:
10.1039/c8cc10004g
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center