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Tissue Eng Part C Methods. 2019 Feb;25(2):59-70. doi: 10.1089/ten.TEC.2018.0324.

Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps.

Author information

1
1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
3
3 George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia.
4
4 School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.
5
5 Department of Orthopedics, Emory University, Atlanta, Georgia.
6
6 Atlanta Veteran's Affairs Medical Center, Decatur, Georgia.

Abstract

The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between fibrosis and regeneration as a function of injury size in the mouse quadriceps. There is currently limited understanding of what leads to a critically sized muscle defect and which muscle regenerative components are functionally impaired. With the substantial increase in preclinical VML models as testbeds for tissue engineering therapeutics, defining the critical threshold for VML injuries will be instrumental in characterizing therapeutic efficacy and potential for subsequent translation.

KEYWORDS:

neuromuscular junction; satellite cells; skeletal muscle; volumetric muscle loss

PMID:
30648479
PMCID:
PMC6389771
[Available on 2020-02-01]
DOI:
10.1089/ten.TEC.2018.0324

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