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Phytother Res. 2019 Jan 15. doi: 10.1002/ptr.6258. [Epub ahead of print]

Impact of curcumin on energy metabolism in HIV infection: A case study.

Author information

1
Center of Health Science, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
2
Department of Physical Education, Centro Universitário do Rio Grande do Norte, Brazil.
3
Department of Physical Education, Centro Universitário Unifacex, Natal, Rio Grande do Norte, Brazil.
4
Department of Nutrition, Federal University of Rio Grande do Norte, Brazil.

Abstract

Prolonged use of antiretroviral therapy (ART) has been associated with dyslipidemia and impaired energy substrate oxidation (SOxi). Curcumin is a natural bioactive compound, which interacts with molecular targets and holds important metabolic properties. The aim of this study was to evaluate the effect of curcumin supplementation on energetic metabolism of an adult female with HIV/AIDS and under ART. The intervention was performed with 500 mg/day of curcumin for 27 days. Glycemic and lipid profile and SOxi at rest were evaluated before and after intervention. After intervention, improvement of lipid profile and insulin sensibility was observed. Moreover, there was a positive modulation of SOxi at rest. Oral curcumin supplementation can positively modulate the energy metabolism of people living with HIV/AIDS using the ART. However, clinical studies are required in order to confirm our findings in a representative sample.

KEYWORDS:

acquired immunodeficiency syndrome; antiretroviral therapy; curcumin; dyslipidemia; energy metabolism

PMID:
30648299
DOI:
10.1002/ptr.6258

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