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Cancer Epidemiol Biomarkers Prev. 2019 Jan 15. pii: cebp.0803.2018. doi: 10.1158/1055-9965.EPI-18-0803. [Epub ahead of print]

Particulate Matter and Traffic-related Exposures in Relation to Breast Cancer Survival.

Author information

1
Chronic Disease Epidemiology, Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School ncd121@mail.harvard.edu.
2
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.
3
Medicine, Channing Laboratory.
4
Channing Division of Network Medicine, Sanofi (United States).
5
Population Medicine, Harvard Medical School & Harvard Pilgrim Health Care Institute.
6
Harvard TH Chan School of Public Health.
7
Environmental Heatlh, Harvard TH Chan School of Public Health.
8
Epidemiology, Harvard TH Chan School of Public Health.

Abstract

BACKGROUND:

While particulate matter (PM) has not been consistently associated with breast cancer risk, two studies have reported harmful associations for breast cancer survival. We examined PM exposures and breast cancer survival in two US-based prospective cohort studies.

METHODS:

The Nurses' Health Study (NHS) and NHSII are cohorts with detailed data on medical history, lifestyle factors, and causes of death. Women with Stage I-III breast cancer (n=8,936) were followed through June 2014. Residential PM was estimated using spatio-temporal models. We performed Cox regression to estimate hazard ratios (HR) of breast cancer specific-mortality and all-cause mortality for 10 μg/m3 increases in post-diagnosis PM.

RESULTS:

There were 1,211 breast cancer specific deaths. Overall, PM was not associated with breast cancer specific mortality (PM2.5: HR=1.09 95% CI 0.87, 1.36; PM2.5-10: HR=1.03 95% CI 0.85, 1.24; PM10: HR=1.05, 95% CI 0.89, 1.24), but was associated with modest increases in all-cause mortality (PM2.5: HR=1.12 95% CI 0.96, 1.30; PM2.5-10: HR=1.12 95% CI 1.00, 1.24; PM10: HR=1.09, 95% CI 1.01, 1.18). However, among participants with Stage I disease PM2.5 was associated with higher breast cancer specific-mortality (HR=1.64 95% CI 1.11, 2.43).

CONCLUSIONS:

PM was not associated with breast cancer specific death overall; however, higher PM was associated with all-cause mortality. Higher PM2.5 was associated with higher breast cancer mortality among Stage I breast cancer patients even after adjustment.

IMPACT:

Studies on ambient PM and breast cancer survival demonstrate that PM2.5 may have broader health effects than previously recognized and warrants further research on breast tumor progression.

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