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Free Radic Res. 2019 Jan 16:1-12. doi: 10.1080/10715762.2018.1563688. [Epub ahead of print]

Melatonin supplementation improves oxidative and inflammatory state in the blood of professional athletes during the preparatory period for competitions.

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a Department of Nuclear Medicine , Oncology Centre prof. Franciszek Łukaszczyk Memorial , Bydgoszcz , Poland.
b Department of Hearing and Vestibular Pathophysiology , Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.
c Department of Neurosurgery , Stanisław Staszic Specialist Hospital , Piła , Poland.
d Department of Medical Biology and Biochemistry , Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.


Melatonin supplementation has been proved to have antioxidant and anti-inflammatory effects in humans. The aim of the study was to estimate the influence of a 30-day melatonin supplementation on oxidative and inflammatory state in the blood of intense training professional athletes. The study was conducted in 47 football players, 19 rowers, and 15 adults who did not practice sports (control group). Blood samples were taken once from the control group and twice from the athletes: before and after 30-day melatonin administration (5 mg daily before sleep). Serum levels of melatonin, isoprostanes, antiox-LDL antibodies, interleukin-6, and C-reactive protein were measured. In erythrocytes, the concentrations of reduced glutathione (GSH) and malondialdehyde (MDA), and the activities of glutathione peroxidase (GSH-Px), cytoplasmic superoxide dismutase (SOD-1), and glutathione reductase (GR) were determined. Melatonin supplementation caused a significant decrease in markers of oxidative stress and a significant increase in melatonin concentration and the activities of SOD-1 and GSH-Px in athletes. The obtained data showed increased oxidative stress and inflammatory processes in professional athletes during intense training and indicated that supplementation of melatonin in their daily diet may have a beneficial effect on the protection of tissues against the adverse action of RONS and inflammatory processes.


Antioxidant defense; athletes; inflammatory processes; melatonin supplementation; oxidative stress

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