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Yeast. 2019 Apr;36(4):167-175. doi: 10.1002/yea.3377. Epub 2019 Jan 30.

André Goffeau's imprinting on second generation yeast "genomologists".

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UMR Génétique Quantitative et Evolution - Le Moulon, INRA - Université Paris-Sud - CNRS - AgroParisTech, Orsay, France.
Institut de Biologie Paris-Seine, Laboratory of Computational and Quantitative Biology, Sorbonne Université, CNRS, Paris, France.
INSERM, IRCAN, Université Côte d'Azur, CNRS, Nice, France.
Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
UMR 7156 Génétique Moléculaire, Génomique, Microbiologie, Université de Strasbourg, CNRS, Strasbourg, France.


All authors of the present paper have worked in labs that participated to the sequencing effort of the Saccharomyces cerevisiae reference genome, and we owe to this the fact that we have all chosen to work on genomics of yeasts. S. cerevisiae has been a popular model species for genetics since the 20th century as well as being a model for general eukaryotic cellular processes. Although it has also been used empirically in fermentation for millennia, there was until recently, a lack of knowledge about the natural and evolutionary history of this yeast. The achievement of the international effort to sequence its genome was the foundation for understanding many eukaryotic biological processes but also represented the first step towards the study of the genome and ecological diversity of yeast populations worldwide. We will describe recent advances in yeast comparative and population genomics that find their origins in the S. cerevisiae genome project initiated and pursued by André Goffeau.


André Goffeau; Saccharomyces cerevisiae; genome sequence; genomics

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