Format

Send to

Choose Destination
Nat Rev Neurosci. 2019 Feb;20(2):94-108. doi: 10.1038/s41583-018-0113-1.

Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.

Author information

1
The University of Edinburgh Centre for Discovery Brain Sciences, UK Dementia Research Institute, Edinburgh, UK.
2
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
3
The University of Edinburgh Centre for Discovery Brain Sciences, UK Dementia Research Institute, Edinburgh, UK. tara.spires-jones@ed.ac.uk.

Abstract

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests that the intricate balance of interactions between neurons, astrocytes, microglia and vascular cells required for healthy brain function becomes perturbed during the disease, with early changes likely protecting neural circuits from damage, followed later by harmful effects when the balance cannot be restored. Moving beyond a neuronal focus to understand the complex cellular interactions in Alzheimer disease and how these change throughout the course of the disease may provide important insight into developing effective therapeutics.

PMID:
30643230
DOI:
10.1038/s41583-018-0113-1

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center