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Int J Mol Sci. 2019 Jan 12;20(2). pii: E289. doi: 10.3390/ijms20020289.

Metabolomic Approach in STEMI-Patients Undergoing Left Ventricular Remodeling.

Author information

1
Institut Mitovasc, University of Angers, University Hospital of Angers, 49000 Angers, France.
2
UMR CNRS 6015-INSERMU1083, 49000 Angers, France.
3
Department of Cardiology, University Hospital of Angers, 49000 Angers, France.
4
Department of Biochemistry, University Hospital of Angers, 49000 Angers, France.
5
Institut Mitovasc, University of Angers, University Hospital of Angers, 49000 Angers, France. lobiere@chu-angers.fr.
6
UMR CNRS 6015-INSERMU1083, 49000 Angers, France. lobiere@chu-angers.fr.
7
Department of Cardiology, University Hospital of Angers, 49000 Angers, France. lobiere@chu-angers.fr.

Abstract

Left ventricular remodeling (LVR) occurring after ST-segment elevation myocardial infarction (STEMI) is frequent and severe. We present a metabolomic approach as an attempt to reveal unknown biomarkers associated with post-STEMI LVR. Out of 192 consecutive patients with successfully revascularized STEMI, 32 presented LVR and were clinically matched with 32 no-LVR patients. They underwent cardiac magnetic resonance at baseline, three months and 12 months. Blood samples were collected during index hospitalization. Creatine kinase (CK) peak and inflammatory markers were higher for LVR patients compared to no-LVR patients (mean 3466 ± 2211 and 2394 ± 1615 UI/L respectively, p = 0.005 for CK peak; mean 35.9 ± 44.3 vs. 21.7 ± 30.4 mg/L respectively, p = 0.020 for C-reactive protein). Leukocyte and neutrophil counts were also higher for LVR patients (mean 12028 ± 2593/mL vs. 10346 ± 3626/mL respectively, p = 0.028 and mean 9035 ± 3036/mL vs. 7596 ± 3822/mL respectively, p < 0.001). For metabolomic analysis, sphingomyelin C20:2 and symmetrical dimethylarginine were higher for LVR patients, but did not reach significance after the correction for the alpha risk. The metabolomic approach did not discriminate patients with and without LVR. However, common parameters that focus on infarction severity, such as infarct size and inflammatory markers, differed between the groups.

KEYWORDS:

cardiac magnetic resonance; left ventricular remodeling; metabolomics; myocardial infarction

PMID:
30642070
PMCID:
PMC6358808
DOI:
10.3390/ijms20020289
[Indexed for MEDLINE]
Free PMC Article

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