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Int J Mol Sci. 2019 Jan 11;20(2). pii: E277. doi: 10.3390/ijms20020277.

Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review.

Author information

1
Department of Surgery, Dentistry, Paediatric and Gynaecology, University of Verona. Policlinico G. B. Rossi. Piazzale L. Scuro n.10, 37134 Verona, Italy. francesca.zotti@univr.it.
2
Department of Surgery, Dentistry, Paediatric and Gynaecology, University of Verona. Policlinico G. B. Rossi. Piazzale L. Scuro n.10, 37134 Verona, Italy. massimo.albanese@univr.it.
3
Section of Anatomy and Pathophysiology, Department of Clinical and Experimental Sciences, University of Brescia, 25100 Brescia, Italy. luigi.rodella@unibs.it.
4
Department of Surgery, Dentistry, Paediatric and Gynaecology, University of Verona. Policlinico G. B. Rossi. Piazzale L. Scuro n.10, 37134 Verona, Italy. pierfrancesco.nocini@univr.it.

Abstract

BACKGROUND:

The aims of this narrative review were to examine up-to-date literature in order to evaluate the effectiveness of arthrocentesis or injections with platelet-rich plasma in temporomandibular affections and to compare them to arthrocentesis alone or with hyaluronic acid (HA) or to hyaluronic acid injections.

METHODS:

The search of international literature was made on the PMC, PubMed and Cochrane databases, including all full-length text of studies on humans focused on osteoarthritis and disc displacements and their treatment with platelet-rich plasma arthrocentesis or injections. All design studies were included in the review and they were examined for three different outcomes: pain, joint sound and mandibular motion. English papers were only selected.

RESULTS:

Even though the low number of studies in this field, arthrocentesis with platelet-rich plasma and platelet-rich plasma injections in temporomandibular disorders' management were found to be effective in reducing pain and joint sound as well as in improving mandibular motion in a maximum follow-up of 24 months.

CONCLUSION:

Comparison to arthrocentesis alone or to HA use in arthrocentesis or by injections provided encouraging results in terms of the effectiveness of platelet-rich plasma use.

KEYWORDS:

arthrocentesis; hyaluronic acid; injection; platelet-rich plasma; temporomandibular joint (TMJ); temporomandibular joint disorders (TMD)

PMID:
30641957
PMCID:
PMC6358929
DOI:
10.3390/ijms20020277
[Indexed for MEDLINE]
Free PMC Article

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