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Mar Drugs. 2019 Jan 11;17(1). pii: E51. doi: 10.3390/md17010051.

The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw.

Author information

1
Department of Oral & Maxillofacial Surgery, Kyung Hee University Dental Hospital at Gangdong, Kyung Hee University, Seoul 153-782, Korea. verycutebear@hanmail.net.
2
Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, Korea. hhyun@chonnam.ac.kr.
3
Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju 61469, Korea. minsunglss@naver.com.
4
Department of Dental Hygiene, College of Health Sciences, Cheongju University, Cheongju 28503, Korea. goodany00@gmail.com.
5
Department of Oral and Maxillofacial Radiology, Kyung Hee University, Seoul 02447, Korea. latinum.omfr@khu.ac.kr.
6
Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. umsewook@gmail.com.
7
Department of Dentistry, Catholic Kwandong University, School of Medicine, International St. Mary's Hospital, Incheon 22711, Korea. cathead81@naver.com.
8
Department of Biomedical Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. chunhj@catholic.ac.kr.
9
Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. yangdh@catholic.ac.kr.

Abstract

Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.

KEYWORDS:

bisphosphonate; bisphosphonate-related osteonecrosis of the jaw; blood vessels; necrotic bone percentages; osteoclasts; polydeoxyribonucleotide

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