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Viruses. 2019 Jan 11;11(1). pii: E49. doi: 10.3390/v11010049.

Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus.

Author information

1
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. batista_m.n@hotmail.com.
2
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. anabragga@gmail.com.
3
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. guilhermecampos07@gmail.com.
4
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. marcosmichel@gmail.com.
5
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. renatapram@hotmail.com.
6
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. tairinezlopes@gmail.com.
7
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. naty_candido@ig.com.br.
8
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. mle.lima94@gmail.com.
9
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. francielly.cristinam@gmail.com.
10
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. teph94@gmail.com.
11
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. cibittar@gmail.com.
12
Departamento de Doenças Infecciosas e Parasitárias, FAMERP, São José do Rio Preto 15090-000, São Paulo, Brazil. mnogueira@famerp.br.
13
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. brunocopo@yahoo.com.br.
14
Institute of Exact and Natural Science, Mato Grosso Federal University, Rondonópolis 78060-900, Mato Grosso, Brazil. brunocopo@yahoo.com.br.
15
Department of Physics, Multiuser Center for Biomolecular Innovation, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil;ricardomariutti@yahoo.com.br (R.B.M.). ricardomariutti@yahoo.com.br.
16
Department of Physics, Multiuser Center for Biomolecular Innovation, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil;ricardomariutti@yahoo.com.br (R.B.M.). arni@ibilce.unesp.br.
17
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. macal131@gmail.com.
18
Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil. rahalp@yahoo.com.br.

Abstract

Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.

KEYWORDS:

Vero E6 cells; ZIKV; berberin; emodin

PMID:
30641880
PMCID:
PMC6356660
DOI:
10.3390/v11010049
[Indexed for MEDLINE]
Free PMC Article

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