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Diabetes Metab Syndr. 2019 Jan - Feb;13(1):542-547. doi: 10.1016/j.dsx.2018.11.008. Epub 2018 Nov 3.

The effects of vitamin D supplementation on lipid profiles and oxidative indices among diabetic nephropathy patients with marginal vitamin D status.

Author information

1
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Chronic Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Department of Nutrition, Nutrition Research & Food Research Institute of Iran, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: pourghassemb@tbzmed.ac.ir.

Abstract

AIMS:

Diabetic nephropathy is one of the major microvascular complications of type 2 diabetes which insufficient vitamin D might -have a role in it's incidence. This study evaluated the effects of vitamin D supplementation on lipid profiles and oxidative/anti-oxidative indices in marginal vitamin D status patients with diabetic nephropathy.

METHODS:

For the current paralleled, randomized, double-blinded, placebo-controlled clinical trial, 50 diabetic nephropathy patients with marginal serum vitamin D were selected. Intervention group received 1,25-dihydroxycholecalciferol (50000 IU/week, n = 25), and placebo group (n = 25) received an identical placebo, for 8 weeks. Lipid profiles (LDL, HDL, TG and TC) and oxidative/anti-oxidative markers (TAC, SOD, CAT, GPX and MDA) were measured.

RESULTS:

Vitamin D supplementation significantly increased vitamin D status in the intervention group, compared to the control group (P = 0.001). The reductions in the serum levels of TG, LDL and TC were significant (P = 0.04, P = 0.006 and P = 0.02, respectively) in the intervention group. The changes in oxidative/anti-oxidative markers and HDL levels were not significant after intervention.

CONCLUSION:

In conclusion, vitamin D supplementation for 8 weeks among diabetic nephropathy patients has beneficial effects on serum vitamin D status and dyslipidemia.

KEYWORDS:

Diabetes; Nephropathy; Vitamin D

PMID:
30641762
DOI:
10.1016/j.dsx.2018.11.008
[Indexed for MEDLINE]

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