Use of implantable pumps for central nervous system drug infusions to treat neurological disease

Neurosurgery. 1988 Dec;23(6):693-8. doi: 10.1227/00006123-198812000-00001.

Abstract

Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating neurological disease by the appropriate manipulation of neurotransmitters, neuromodulators, and neurohormones. Clinical application of this knowledge has been inhibited, however, by long-standing problems with drug delivery to the central nervous system (CNS). The availability of implantable drug infusion pumps and stereotactic catheter placement techniques may overcome many of these problems. The problems of drug delivery to the brain and the present and potential uses of implantable drug pumps for neurological disease are discussed. In addition, the relationship between CNS drug infusion and neural tissue transplantation is briefly reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Brain Neoplasms / drug therapy
  • Humans
  • Infusion Pumps*
  • Injections, Spinal
  • Nervous System Diseases / drug therapy*
  • Pain / drug therapy