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Bioorg Med Chem Lett. 2019 Feb 15;29(4):619-622. doi: 10.1016/j.bmcl.2018.12.048. Epub 2018 Dec 22.

Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.

Author information

1
Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA. Electronic address: chg3@lehigh.edu.
2
Department of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
3
Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA.
4
Department of Environmental Health Science, New York Medical College, Valhalla, NY 10595, USA.

Abstract

Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

KEYWORDS:

8-MOP; 8-Methoxypsoralen; Dark-reaction toxicity; Keratinocytes; PAM212; Phototoxicity

PMID:
30638875
PMCID:
PMC6364570
[Available on 2020-02-15]
DOI:
10.1016/j.bmcl.2018.12.048

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