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Neurol Res. 2019 Apr;41(4):341-353. doi: 10.1080/01616412.2018.1564191. Epub 2019 Jan 13.

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Author information

1
a Department of Neurology , University of Leipzig , Leipzig , Germany.
2
b Institute of Anatomy , University of Leipzig , Leipzig , Germany.
3
c Department of Neurology , University of Würzburg , Würzburg , Germany.
4
d Department of Medicine , University of Leipzig , Leipzig , Germany.
5
e Integrated Research and Treatment Center (IFB) Adiposity Disease , Leipzig , Germany.
6
f Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM) , University of Leipzig , Leipzig , German.
7
g Heart Center , University of Leipzig , Leipzig , Germany.

Abstract

INTRODUCTION:

Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

METHODS:

Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

RESULTS:

We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Low dietary iron load caused more pronounced abnormalities than high iron load in ob/ob mice.

DISCUSSION:

Our data suggest that dietary non-heme iron deficiency may be a modulating factor in the pathogenesis of peripheral neuropathy in obese ob/ob mice with metabolic syndrome. Once the mechanisms can be further elucidated, how low dietary iron augments peripheral nerve degeneration and dysfunction via pro-inflammatory pathways and new therapeutic strategies could be developed.

ABBREVIATIONS:

CMAP: compound muscle action potential; cSNCV: compound sensory nerve conduction velocity; IENFD: intraepidermal nerve fiber density; LDL: low-density lipoprotein; MetS: metabolic syndrome; MNCV: motor conduction velocity; NCV: nerve conduction velocity; PN: peripheral neuropathy; PNS: peripheral nervous system; STZ: streptozotocin; T2D: type 2 diabetes mellitus; TNF alpha: tumor necrosis factor alpha; WHO: World Health Organization.

KEYWORDS:

mice; Peripheral neuropathy; iron; metabolic syndrome; nerve inflammation

PMID:
30638160
DOI:
10.1080/01616412.2018.1564191
[Indexed for MEDLINE]

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