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Tissue Eng Part A. 2019 Aug 9. doi: 10.1089/ten.TEA.2018.0288. [Epub ahead of print]

A Method for High-Throughput Robotic Assembly of Three-Dimensional Vascular Tissue.

Author information

1
1Robotics Engineering Program, Worcester Polytechnic Institute, Worcester, Massachusetts.
2
2Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts.
3
3Mechanical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts.

Abstract

Self-assembled tissues have potential to serve both as implantable grafts and as tools for disease modeling and drug screening. For these applications, tissue production must ultimately be scaled-up and automated. Limited technologies exist for precisely manipulating self-assembled tissues, which are fragile early in culture. Here, we presented a method for automatically stacking self-assembled smooth muscle cell rings onto mandrels, using a custom-designed well plate and robotic punch system. Rings then fuse into tissue-engineered blood vessels (TEBVs). This is a critical step toward automating TEBV production that may be applied to other tubular tissues as well.

KEYWORDS:

additive manufacturing; biofabrication; self-assembly; tissue manipulation; tissue-engineered blood vessel

PMID:
30638142
DOI:
10.1089/ten.TEA.2018.0288

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