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J Cell Mol Med. 2019 Mar;23(3):2268-2271. doi: 10.1111/jcmm.14153. Epub 2019 Jan 13.

Circulating serum vitamin D levels and total body bone mineral density: A Mendelian randomization study.

Author information

1
Department of orthopedics, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Gangwon, Republic of Korea.
2
Department of orthopedics, Taian City Central Hospital, Taian, Shandong, P.R. China.
3
Affiliated Hospital & Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, P.R. China.
4
Second School of Clinical Medicine, Taishan Medical University, Taian, Shandong, P.R. China.

Abstract

Until recently, randomized controlled trials have not demonstrated convincing evidence that vitamin D, or vitamin D in combination with calcium supplementation could improve bone mineral density (BMD), osteoporosis and fracture. It remains unclear whether vitamin D levels are causally associated with total body BMD. Here, we performed a Mendelian randomization study to investigate the association of vitamin D levels with total body BMD using a large-scale vitamin D genome-wide association study (GWAS) dataset (including 79 366 individuals) and a large-scale total body BMD GWAS dataset (including 66,628 individuals). We selected three Mendelian randomization methods including inverse-variance weighted meta-analysis (IVW), weighted median regression and MR-Egger regression. All these three methods did not show statistically significant association of genetically increased vitamin D levels with total body BMD. Importantly, our findings are consistent with recent randomized clinical trials and Mendelian randomization study. In summary, we provide genetic evidence that increased vitamin D levels could not improve BMD in the general population. Hence, vitamin D supplementation alone may not be associated with reduced fracture incidence among community-dwelling adults without known vitamin D deficiency, osteoporosis, or prior fracture.

KEYWORDS:

Mendelian randomization; bone mineral density; vitamin D

PMID:
30637964
DOI:
10.1111/jcmm.14153
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