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Br J Ophthalmol. 2019 Jan 12. pii: bjophthalmol-2018-312349. doi: 10.1136/bjophthalmol-2018-312349. [Epub ahead of print]

Inner macular layer thickness by spectral domain optical coherence tomography in children and adults: a hospital-based study.

Author information

1
Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South Korea.
2
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
3
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea nan282@snu.ac.kr.
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Contributed equally

Abstract

PURPOSE:

To establish the normative ranges of macular ganglion cell layer (mGCL) and macular inner plexiform layer (mIPL) thickness using Spectralis spectral domain optical coherence tomography (SD-OCT) (Heidelberg Engineering, Inc., Heidelberg, Germany) in both Korean children and adults, and to determine factors associated with mGCL and mIPL thickness.

METHODS:

We conducted a retrospective, observational study of 573 healthy subjects (5-70 years old) who underwent comprehensive ophthalmic examinations in a single institution. Each inner retinal layer thickness was measured using SD-OCT and automatic segmentation software. Cross-sectional analysis was used to evaluate the effect of gender, age and ocular parameters on mGCL and mIPL thickness. Normative ranges of mGCL and mIPL thickness according to age, gender and factors associated with mGCL and mIPL thickness were measured.

RESULTS:

The mean mGCL and mIPL thickness were 40.6±2.8 and 33.8±2.0 µm, respectively. Determinants of inner sector mGCL thickness were circumpapillary retinal nerve fibre layer (cpRNFL) thickness (β=1.172, p<0.001), age (β=-0.019, p=0.021) and male gender (β=1.452, p<0.001). Determinants of inner sector mIPL thickness were cpRNFL (β=0.952, p<0.001) and male gender (β=1.163, p<0.001). The inner sector mGCL and mIPL thickness increased significantly with age in children (β=0.174, p=0.009 and β=0.115, p=0.013), and then decreased in adults (β=-0.070, p<0.001 and β=-0.024, p=0.032). In the case of outer sectors, mGCL and mIPL thickness were not significantly related to age and gender.

CONCLUSIONS:

This study ensured a normative range of the mGCL and mIPL thickness using Spectralis OCT. Gender, age and cpRNFL thickness significantly correlated with mGCL and mIPL thickness. This information should be considered in the interpretation of SD-OCT data.

KEYWORDS:

diagnostic tests/investigation; imaging; optic nerve; retina

Conflict of interest statement

Competing interests: None declared.

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