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BMJ Case Rep. 2019 Jan 10;12(1). pii: bcr-2018-226738. doi: 10.1136/bcr-2018-226738.

Ocular hypertension secondary to high endogenous steroid load in Cushing's disease.

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Ophthalmology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Ophthalmology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK.


This case report describes a 35-year-old Caucasian man who was referred to the glaucoma clinic with high intraocular pressure (IOP) after routine optometrist assessment. He was diagnosed with ocular hypertension (OHT) and the management plan was for monitoring without treatment. Three months later, he presented to the endocrine clinic with symptoms of Cushing's disease and was diagnosed with an adrenocorticotropic hormone secreting pituitary microadenoma. His symptoms preceded his presentation at both departments by 5 years. He underwent definitive surgical treatment of his adenoma via transsphenoidal resection. At 1-year follow-up in glaucoma clinic, it was noted that his IOP had normalised. Due to his high endogenous cortisol level at diagnosis, long disease duration, the pattern of IOP rise and subsequent normalisation after treatment, it is suggestive that his OHT is secondary to his Cushing's disease. There are infrequent reports of this association in published literature.


endocrinology; glaucoma; ophthalmology; pituitary disorders

[Indexed for MEDLINE]

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